MultiOme Explorer

Rare genetic diseases affect various levels of biological organization between the genome and the whole organism. You can find a general introduction on this topic here. In 2021, we published a comprehensive analysis of 3,771 rare diseases and a their connection patterns on a multiplex network consisting of over 20 million gene relationships that are organized into 46 network layers spanning six major biological scales between genotype and phenotype. You can explore the results and investigate the connections among genes associated to a disease of interest in our interactive webapp. The code for all analyses presented in the paper can be found on our github page. The repository also contains a walk-through guide for reproducing the figures and analyses.